7U9S

Crystal structure of human D-amino acid oxidase in complex with inhibitor

7U9S の概要

• エントリーDOI: 10.2210/pdb7u9s/pdb
• 分子名称: D-amino-acid oxidase, FLAVIN-ADENINE DINUCLEOTIDE, 5-{2-[4-(trifluoromethyl)phenyl]ethyl}-1,4-dihydropyrazine-2,3-dione, ... (4 entities in total)
• 機能のキーワード: fad, flavoprotein, oxidoreductase, peroxisome, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81181.39

構造登録者

Skene, R.J.,Bell, J.A. (登録日: 2022-03-11, 公開日: 2022-06-08, 最終更新日: 2023-10-18)

• 主引用文献: Tang, H.,Jensen, K.,Houang, E.,McRobb, F.M.,Bhat, S.,Svensson, M.,Bochevarov, A.,Day, T.,Dahlgren, M.K.,Bell, J.A.,Frye, L.,Skene, R.J.,Lewis, J.H.,Osborne, J.D.,Tierney, J.P.,Gordon, J.A.,Palomero, M.A.,Gallati, C.,Chapman, R.S.L.,Jones, D.R.,Hirst, K.L.,Sephton, M.,Chauhan, A.,Sharpe, A.,Tardia, P.,Dechaux, E.A.,Taylor, A.,Waddell, R.D.,Valentine, A.,Janssens, H.B.,Aziz, O.,Bloomfield, D.E.,Ladha, S.,Fraser, I.J.,Ellard, J.M.; Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrodinger Computational Platform.; J.Med.Chem., 65:6775-6802, 2022; PubMed: 35482677; DOI: 10.1021/acs.jmedchem.2c00118

実験手法

X-RAY DIFFRACTION (2.1 Å)