7U99
EGFR kinase in complex with a macrocyclic inhibitor
Summary for 7U99
Entry DOI | 10.2210/pdb7u99/pdb |
Descriptor | Epidermal growth factor receptor, 19-chloro-22-methoxy-8,9,11,12,14,15-hexahydro-21H-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine, CITRATE ANION, ... (4 entities in total) |
Functional Keywords | egfr, kinase, macrocycle, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38257.41 |
Authors | Beyett, T.S.,Eck, M.J. (deposition date: 2022-03-10, release date: 2022-11-23, Last modification date: 2023-10-25) |
Primary citation | Amrhein, J.A.,Beyett, T.S.,Feng, W.W.,Kramer, A.,Weckesser, J.,Schaeffner, I.K.,Rana, J.K.,Janne, P.A.,Eck, M.J.,Knapp, S.,Hanke, T. Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. J.Med.Chem., 65:15679-15697, 2022 Cited by PubMed: 36384036DOI: 10.1021/acs.jmedchem.2c01041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report