7U8Z
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with fluorinated peptoid inhibitor
Summary for 7U8Z
Entry DOI | 10.2210/pdb7u8z/pdb |
Descriptor | Hdac6 protein, ACETATE ION, 4-({N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)benzamido}methyl)-3-fluoro-N-hydroxybenzamide, ... (9 entities in total) |
Functional Keywords | hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Danio rerio (zebrafish) |
Total number of polymer chains | 4 |
Total formula weight | 164256.01 |
Authors | Watson, P.R.,Cragin, A.D.,Christianson, D.W. (deposition date: 2022-03-09, release date: 2022-11-23, Last modification date: 2023-10-25) |
Primary citation | Ressing, N.,Schliehe-Diecks, J.,Watson, P.R.,Sonnichsen, M.,Cragin, A.D.,Scholer, A.,Yang, J.,Schaker-Hubner, L.,Borkhardt, A.,Christianson, D.W.,Bhatia, S.,Hansen, F.K. Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia. J.Med.Chem., 65:15457-15472, 2022 Cited by PubMed: 36351184DOI: 10.1021/acs.jmedchem.2c01418 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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