7U8Z

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with fluorinated peptoid inhibitor

7U8Z の概要

• エントリーDOI: 10.2210/pdb7u8z/pdb
• 分子名称: Hdac6 protein, ACETATE ION, 4-({N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)benzamido}methyl)-3-fluoro-N-hydroxybenzamide, ... (9 entities in total)
• 機能のキーワード: hydrolase, histone deacetylase, inhibitor, metallohydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 164256.01

構造登録者

Watson, P.R.,Cragin, A.D.,Christianson, D.W. (登録日: 2022-03-09, 公開日: 2022-11-23, 最終更新日: 2023-10-25)

• 主引用文献: Ressing, N.,Schliehe-Diecks, J.,Watson, P.R.,Sonnichsen, M.,Cragin, A.D.,Scholer, A.,Yang, J.,Schaker-Hubner, L.,Borkhardt, A.,Christianson, D.W.,Bhatia, S.,Hansen, F.K.; Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.; J.Med.Chem., 65:15457-15472, 2022; PubMed: 36351184; DOI: 10.1021/acs.jmedchem.2c01418

実験手法

X-RAY DIFFRACTION (1.85 Å)