7U6A

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 3-thienylmethyl Benzhydroxamic Acid Inhibitor

7U6A の概要

• エントリーDOI: 10.2210/pdb7u6a/pdb
• 分子名称: Polyamine deacetylase HDAC10, N-hydroxy-4-({[(thiophen-3-yl)methyl]amino}methyl)benzamide, 1,2-ETHANEDIOL, ... (7 entities in total)
• 機能のキーワード: histone deacetylase, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75808.55

構造登録者

Herbst-Gervasoni, C.J.,Christianson, D.W. (登録日: 2022-03-03, 公開日: 2022-04-06, 最終更新日: 2023-10-18)

• 主引用文献: Zeyen, P.,Zeyn, Y.,Herp, D.,Mahmoudi, F.,Yesiloglu, T.Z.,Erdmann, F.,Schmidt, M.,Robaa, D.,Romier, C.,Ridinger, J.,Herbst-Gervasoni, C.J.,Christianson, D.W.,Oehme, I.,Jung, M.,Kramer, O.H.,Sippl, W.; Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells.; Eur.J.Med.Chem., 234:114272-114272, 2022; PubMed: 35306288; DOI: 10.1016/j.ejmech.2022.114272

実験手法

X-RAY DIFFRACTION (2.25 Å)