7U3L
GID4 in complex with compound 91
Summary for 7U3L
Entry DOI | 10.2210/pdb7u3l/pdb |
Descriptor | Glucose-induced degradation protein 4 homolog, Nalpha-{(2R,4E)-2-[(N-benzylglycyl)amino]-5-phenylpent-4-enoyl}-N,4-dimethyl-L-phenylalaninamide, GLYCEROL, ... (4 entities in total) |
Functional Keywords | complex, inhibitor, protein degradation, peptide binding protein, peptide binding protein-inhibitor complex, peptide binding protein/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 20209.51 |
Authors | Chana, C.K.,Sicheri, F. (deposition date: 2022-02-27, release date: 2022-10-05, Last modification date: 2023-10-18) |
Primary citation | Chana, C.K.,Maisonneuve, P.,Posternak, G.,Grinberg, N.G.A.,Poirson, J.,Ona, S.M.,Ceccarelli, D.F.,Mader, P.,St-Cyr, D.J.,Pau, V.,Kurinov, I.,Tang, X.,Deng, D.,Cui, W.,Su, W.,Kuai, L.,Soll, R.,Tyers, M.,Rost, H.L.,Batey, R.A.,Taipale, M.,Gingras, A.C.,Sicheri, F. Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65:12725-12746, 2022 Cited by PubMed: 36117290DOI: 10.1021/acs.jmedchem.2c00509 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.295 Å) |
Structure validation
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