7U3E

GID4 in complex with compound 1

7U3E の概要

• エントリーDOI: 10.2210/pdb7u3e/pdb
• 分子名称: Glucose-induced degradation protein 4 homolog, tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (3 entities in total)
• 機能のキーワード: complex, inhibitor, protein degradation, peptide binding protein, peptide binding protein-inhibitor complex, peptide binding protein/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39606.08

構造登録者

Chana, C.K.,Sicheri, F. (登録日: 2022-02-27, 公開日: 2022-10-05, 最終更新日: 2023-10-18)

• 主引用文献: Chana, C.K.,Maisonneuve, P.,Posternak, G.,Grinberg, N.G.A.,Poirson, J.,Ona, S.M.,Ceccarelli, D.F.,Mader, P.,St-Cyr, D.J.,Pau, V.,Kurinov, I.,Tang, X.,Deng, D.,Cui, W.,Su, W.,Kuai, L.,Soll, R.,Tyers, M.,Rost, H.L.,Batey, R.A.,Taipale, M.,Gingras, A.C.,Sicheri, F.; Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4.; J.Med.Chem., 65:12725-12746, 2022; PubMed: 36117290; DOI: 10.1021/acs.jmedchem.2c00509

実験手法

X-RAY DIFFRACTION (1.852 Å)