7U2H

Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA, aminoacylated A-site Gly-NH-tRNAgly, aminoacylated P-site fMet-NH-tRNAmet, and deacylated E-site tRNAgly at 2.55A resolution

これはPDB形式変換不可エントリーです。

7U2H の概要

• エントリーDOI: 10.2210/pdb7u2h/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• 機能のキーワード: chloramphenicol; antibiotic; glycine; non-hydrolyzable; aminoacyl-trna; peptidyl-trna; 70s ribosome; x-ray structure; pre-attack state; transpeptidation; peptidyl transferase center; context-specificity of drug action; inhibition of translation; uncompetitive inhibitor, ribosome
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4566191.36

構造登録者

Syroegin, E.A.,Aleksandrova, E.V.,Polikanov, Y.S. (登録日: 2022-02-24, 公開日: 2022-07-13, 最終更新日: 2023-11-15)

• 主引用文献: Syroegin, E.A.,Aleksandrova, E.V.,Polikanov, Y.S.; Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine.; Nucleic Acids Res., 50:7669-7679, 2022; PubMed: 35766409; DOI: 10.1093/nar/gkac548

実験手法

X-RAY DIFFRACTION (2.55 Å)