7U0U
Crystal Structure of a Aspergillus fumigatus Calcineurin A - Calcineurin B fusion bound to FKBP12 and FK-506
Summary for 7U0U
Entry DOI | 10.2210/pdb7u0u/pdb |
Descriptor | Serine/threonine-protein phosphatase 2B catalytic subunit,AsfuA.00174.a.TQ11 + AsfuA.01011.a.TR11, Peptidylprolyl isomerase, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | ssgcid, calcineurin, cna, cnb, fkbp12, peptidyl prolyl cis-trans isomerase, phosphatase, fk-506, tacrolimus, structural genomics, seattle structural genomics center for infectious disease, antifungal protein |
Biological source | Aspergillus fumigatus More |
Total number of polymer chains | 2 |
Total formula weight | 45349.77 |
Authors | Fox III, D.,Abendroth, J.,DeBouver, N.D.,Hoy, M.J.,Heitman, J.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2022-02-18, release date: 2022-08-03, Last modification date: 2023-10-18) |
Primary citation | Hoy, M.J.,Park, E.,Lee, H.,Lim, W.Y.,Cole, D.C.,DeBouver, N.D.,Bobay, B.G.,Pierce, P.G.,Fox 3rd, D.,Ciofani, M.,Juvvadi, P.R.,Steinbach, W.,Hong, J.,Heitman, J. Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. Mbio, 13:e0104922-e0104922, 2022 Cited by PubMed: 35604094DOI: 10.1128/mbio.01049-22 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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