7U0A

Crystal Structure of C77G12 Fab in complex with SARS-CoV-2 S fusion peptide

7U0A の概要

• エントリーDOI: 10.2210/pdb7u0a/pdb
• 分子名称: SARS-CoV-2 S fusion peptide, Heavy chain Fab C77G12, Light chain Fab C77G12, ... (5 entities in total)
• 機能のキーワード: sars-cov-2 spike, covid-19, fusion peptide, fab, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48977.95

構造登録者

Tortorici, M.A.,Veesler, D. (登録日: 2022-02-17, 公開日: 2022-08-03, 最終更新日: 2023-10-18)

• 主引用文献: Low, J.S.,Jerak, J.,Tortorici, M.A.,McCallum, M.,Pinto, D.,Cassotta, A.,Foglierini, M.,Mele, F.,Abdelnabi, R.,Weynand, B.,Noack, J.,Montiel-Ruiz, M.,Bianchi, S.,Benigni, F.,Sprugasci, N.,Joshi, A.,Bowen, J.E.,Stewart, C.,Rexhepaj, M.,Walls, A.C.,Jarrossay, D.,Morone, D.,Paparoditis, P.,Garzoni, C.,Ferrari, P.,Ceschi, A.,Neyts, J.,Purcell, L.A.,Snell, G.,Corti, D.,Lanzavecchia, A.,Veesler, D.,Sallusto, F.; ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.; Science, 377:735-742, 2022; PubMed: 35857703; DOI: 10.1126/science.abq2679

実験手法

X-RAY DIFFRACTION (1.7 Å)