7TZU

Crystal structure of the E. coli thiM riboswitch bound to 1-(4-(piperazin-1-yl)pyridin-3-yl)-N-(quinoxalin-6-ylmethyl)methanamine (linked compound 38)

Summary for 7TZU

Entry DOI	10.2210/pdb7tzu/pdb
Descriptor	RNA (79-MER), 1-[4-(piperazin-1-yl)pyridin-3-yl]-N-[(quinoxalin-6-yl)methyl]methanamine, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	thim tpp riboswitch, rna
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	27401.72
Authors	Nuthanakanti, A.,Serganov, A. (deposition date: 2022-02-16, release date: 2022-05-25, Last modification date: 2023-10-18)
Primary citation	Zeller, M.J.,Favorov, O.,Li, K.,Nuthanakanti, A.,Hussein, D.,Michaud, A.,Lafontaine, D.A.,Busan, S.,Serganov, A.,Aube, J.,Weeks, K.M. SHAPE-enabled fragment-based ligand discovery for RNA. Proc.Natl.Acad.Sci.USA, 119:e2122660119-e2122660119, 2022 Cited by PubMed: 35561226 DOI: 10.1073/pnas.2122660119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.87 Å)

Structure validation