7TYZ

Cryo-EM structure of SARS-CoV-2 spike in complex with FSR22, an anti-SARS-CoV-2 DARPin

7TYZ の概要

• エントリーDOI: 10.2210/pdb7tyz/pdb
• EMDBエントリー: 26200
• 分子名称: Spike glycoprotein, DARPin FSR22, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: darpins, anti-sars-cov-2, therapeutics, covid-19, viral protein-antiviral protein complex, viral protein/antiviral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 499783.88

構造登録者

Kwon, Y.D.,Gorman, J.,Kwong, P.D. (登録日: 2022-02-15, 公開日: 2022-12-07, 最終更新日: 2023-03-15)

• 主引用文献: Chonira, V.,Kwon, Y.D.,Gorman, J.,Case, J.B.,Ku, Z.,Simeon, R.,Casner, R.G.,Harris, D.R.,Olia, A.S.,Stephens, T.,Shapiro, L.,Bender, M.F.,Boyd, H.,Teng, I.T.,Tsybovsky, Y.,Krammer, F.,Zhang, N.,Diamond, M.S.,Kwong, P.D.,An, Z.,Chen, Z.; A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPins.; Nat.Chem.Biol., 19:284-291, 2023; PubMed: 36411391; DOI: 10.1038/s41589-022-01193-2

実験手法