7TYU

TEAD2 bound to Compound 2

7TYU の概要

• エントリーDOI: 10.2210/pdb7tyu/pdb
• 分子名称: Transcriptional enhancer factor TEF-4, (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: small molecule ppi inhibitor complex, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53554.67

構造登録者

Noland, C.L.,Fong, R. (登録日: 2022-02-14, 公開日: 2023-05-03, 最終更新日: 2023-10-25)

• 主引用文献: Hagenbeek, T.J.,Zbieg, J.R.,Noland, C.L.,Yao, X.,Schmidt, S.,Clausen, S.,Steffek, M.,Lee, W.,Beroza, P.,Martin, S.,Lin, E.,Fong, R.,Di Lello, P.,Kubala, M.H.,Lacap, J.A.,Yang, M.N.Y.,Maddalo, D.,Lau, J.T.,An, L.,Levy, E.,Lorenzo, M.N.,Lee, H.J.,Pham, T.H.,Modrusan, Z.,Zang, R.,Chen, Y.C.,Li, J.,Hafner, M.,Chang, M.T.,Crawford, J.J.,Dey, A.; Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an expanded Hippo dependent landscape in cancers; To Be Published,

実験手法

X-RAY DIFFRACTION (1.78 Å)