7TUR

Joint X-ray/neutron structure of aspastate aminotransferase (AAT) in complex with pyridoxamine 5'-phosphate (PMP)

7TUR の概要

• エントリーDOI: 10.2210/pdb7tur/pdb
• 分子名称: Aspartate aminotransferase, cytoplasmic, 2-[(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL)-AMINO]-2-METHYL-SUCCINIC ACID, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: plp-dependent enzyme, homodimer, aspartate aminotransferase, transferase
• 由来する生物種: Sus scrofa (pig)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 93789.98

構造登録者

Drago, V.N.,Kovalevsky, A.Y.,Dajnowicz, S.,Mueser, T.C. (登録日: 2022-02-03, 公開日: 2022-09-28, 最終更新日: 2023-10-25)

• 主引用文献: Drago, V.N.,Dajnowicz, S.,Parks, J.M.,Blakeley, M.P.,Keen, D.A.,Coquelle, N.,Weiss, K.L.,Gerlits, O.,Kovalevsky, A.,Mueser, T.C.; An N⋯H⋯N low-barrier hydrogen bond preorganizes the catalytic site of aspartate aminotransferase to facilitate the second half-reaction.; Chem Sci, 13:10057-10065, 2022; PubMed: 36128223; DOI: 10.1039/d2sc02285k

実験手法

NEUTRON DIFFRACTION (2.22 Å)
X-RAY DIFFRACTION (1.7 Å)