7TTF

Tubulin-RB3_SLD in complex with compound 12k

7TTF の概要

• エントリーDOI: 10.2210/pdb7ttf/pdb
• 分子名称: Tubulin alpha-1B chain, Tubulin beta chain, Stathmin-4, ... (10 entities in total)
• 機能のキーワード: microtubule inhibitor, colchicine, cell cycle, cancer, inhibitor complex, cell cycle-inhibitor complex, cell cycle/inhibitor
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 215160.98

構造登録者

White, S.W.,Yun, M. (登録日: 2022-02-01, 公開日: 2023-04-12, 最終更新日: 2023-10-25)

• 主引用文献: Pochampally, S.,Hartman, K.L.,Wang, R.,Wang, J.,Yun, M.K.,Parmar, K.,Park, H.,Meibohm, B.,White, S.W.,Li, W.,Miller, D.D.; Design, Synthesis, and Biological Evaluation of Pyrimidine Dihydroquinoxalinone Derivatives as Tubulin Colchicine Site-Binding Agents That Displayed Potent Anticancer Activity Both In Vitro and In Vivo.; Acs Pharmacol Transl Sci, 6:526-545, 2023; PubMed: 37082747; DOI: 10.1021/acsptsci.2c00108

実験手法

X-RAY DIFFRACTION (2.1 Å)