7TS8

Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 4-chloro-6-((5-(2-(dimethylamino)ethyl)-2,3-difluorophenyl)ethynyl)pyridin-2-amine

7TS8 の概要

• エントリーDOI: 10.2210/pdb7ts8/pdb
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor, heme enzyme, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 200874.60

構造登録者

Li, H.,Poulos, T.L. (登録日: 2022-01-31, 公開日: 2022-07-13, 最終更新日: 2023-10-18)

• 主引用文献: Vasu, D.,Li, H.,Hardy, C.D.,Poulos, T.L.,Silverman, R.B.; 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.; Bioorg.Med.Chem., 69:116878-116878, 2022; PubMed: 35772285; DOI: 10.1016/j.bmc.2022.116878

実験手法

X-RAY DIFFRACTION (2.3 Å)