7TRQ

Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154

7TRQ の概要

• エントリーDOI: 10.2210/pdb7trq/pdb
• EMDBエントリー: 26099 26100 26101 26102
• 分子名称: Muscarinic acetylcholine receptor M4, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: 7 transmembrane receptor, signaling protein-immune system complex, signaling protein/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 153253.33

構造登録者

Vuckovic, Z.,Mobbs, J.I.,Belousoff, M.J.,Glukhova, A.,Sexton, P.M.,Danev, R.,Thal, D.M. (登録日: 2022-01-30, 公開日: 2023-05-17)

• 主引用文献: Thal, D.M.; Structural and dynamic mechanisms of allostery at the M4 muscarinic acetylcholine receptor; Elife, 2023

実験手法

ELECTRON MICROSCOPY (2.5 Å)