7TRM

Crystal structure of human BIRC2 BIR3 domain in complex with inhibitor LCL-161

7TRM の概要

• エントリーDOI: 10.2210/pdb7trm/pdb
• 分子名称: Baculoviral IAP repeat-containing protein 2, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: nuclear protein, inhibitor, histone h3, dna binding, apoptosis
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11578.51

構造登録者

Tencer, A.H.,Klein, B.J.,Kutateladze, T.G. (登録日: 2022-01-29, 公開日: 2023-08-02, 最終更新日: 2023-09-20)

• 主引用文献: Tencer, A.H.,Yu, Y.,Causse, S.Z.,Campbell, G.R.,Klein, B.J.,Xuan, H.,Cartier, J.,Miles, M.A.,Gaurav, N.,Zadoroznyj, A.,Holt, T.A.,Wen, H.,Hawkins, C.J.,Spector, S.A.,Dubrez, L.,Shi, X.,Kutateladze, T.G.; Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2.; Nat.Struct.Mol.Biol., 30:1265-1274, 2023; PubMed: 37524969; DOI: 10.1038/s41594-023-01044-1

実験手法

X-RAY DIFFRACTION (2.4 Å)