7TPJ

Single-Particle Cryo-EM Structure of the WaaL O-antigen ligase in its apo state

7TPJ の概要

• エントリーDOI: 10.2210/pdb7tpj/pdb
• EMDBエントリー: 26057
• 分子名称: Putative cell surface polysaccharide polymerase/ligase, Fab Heavy (H) Chain, Fab Light (L) Chain (3 entities in total)
• 機能のキーワード: lipopolysaccharide, single-particle cryo-electron microscopy, molecular dynamics simulations, structural biology, undecaprenyl pyrophosphate, waal ligase, lipid a, o-antigen, membrane proteins, transglycosylation, glycosyltransferase, membrane protein
• 由来する生物種: Cupriavidus metallidurans; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 93010.82

構造登録者

Ashraf, K.U.,Nygaard, R.,Vickery, O.N.,Erramilli, S.K.,Herrera, C.M.,McConville, T.H.,Petrou, V.I.,Giacometti, S.I.,Dufrisne, M.B.,Nosol, K.,Zinkle, A.P.,Graham, C.L.B.,Loukeris, M.,Kloss, B.,Skorupinska-Tudek, K.,Swiezewska, E.,Roper, D.,Clarke, O.B.,Uhlemann, A.C.,Kossiakoff, A.A.,Trent, M.S.,Stansfeld, P.J.,Mancia, F. (登録日: 2022-01-25, 公開日: 2022-04-06, 最終更新日: 2022-04-27)

• 主引用文献: Ashraf, K.U.,Nygaard, R.,Vickery, O.N.,Erramilli, S.K.,Herrera, C.M.,McConville, T.H.,Petrou, V.I.,Giacometti, S.I.,Dufrisne, M.B.,Nosol, K.,Zinkle, A.P.,Graham, C.L.B.,Loukeris, M.,Kloss, B.,Skorupinska-Tudek, K.,Swiezewska, E.,Roper, D.I.,Clarke, O.B.,Uhlemann, A.C.,Kossiakoff, A.A.,Trent, M.S.,Stansfeld, P.J.,Mancia, F.; Structural basis of lipopolysaccharide maturation by the O-antigen ligase.; Nature, 604:371-376, 2022; PubMed: 35388216; DOI: 10.1038/s41586-022-04555-x

実験手法

ELECTRON MICROSCOPY (3.46 Å)