7TNM

Complex GNGN2 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM)

7TNM の概要

• エントリーDOI: 10.2210/pdb7tnm/pdb
• EMDBエントリー: 26011 26012 26013 26014 26015 26016 26017
• 分子名称: Isoform Flip of Glutamate receptor 2,Voltage-dependent calcium channel gamma-3 subunit chimera, GLUTAMIC ACID, CYCLOTHIAZIDE (3 entities in total)
• 機能のキーワード: ampa, iglur, stargazin, cryo-em, complex, agonist, positive allosteric modulator, subconductance level, opening, gating, glutamate, membrane protein
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 463633.46

構造登録者

Yelshanskaya, M.V.,Sobolevsky, A.I. (登録日: 2022-01-21, 公開日: 2022-04-20, 最終更新日: 2022-05-18)

• 主引用文献: Yelshanskaya, M.V.,Patel, D.S.,Kottke, C.M.,Kurnikova, M.G.,Sobolevsky, A.I.; Opening of glutamate receptor channel to subconductance levels.; Nature, 605:172-178, 2022; PubMed: 35444281; DOI: 10.1038/s41586-022-04637-w

実験手法

ELECTRON MICROSCOPY (4.74 Å)