7TLL

Structure of SARS-CoV-2 Mpro Omicron P132H in complex with Nirmatrelvir (PF-07321332)

Summary for 7TLL

• Entry DOI: 10.2210/pdb7tll/pdb
• Related: 7RFS
• Descriptor: 3C-like proteinase nsp5, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide (3 entities in total)
• Functional Keywords: protease, sars-cov-2, covalent complex, inhibitor, hydrolase-inhibitor complex, mutant, omicron, p132h, nirmatrelvir, pf-07321332, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• Total number of polymer chains: 2
• Total formula weight: 68736.24

Authors

Greasley, S.E.,Ferre, R.A.,Plotnikova, O.,Liu, W.,Stewart, A.E. (deposition date: 2022-01-18, release date: 2022-01-26, Last modification date: 2022-06-15)

• Primary citation: Greasley, S.E.,Noell, S.,Plotnikova, O.,Ferre, R.,Liu, W.,Bolanos, B.,Fennell, K.,Nicki, J.,Craig, T.,Zhu, Y.,Stewart, A.E.,Steppan, C.M.; Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants.; J.Biol.Chem., 298:101972-101972, 2022; PubMed: 35461811; DOI: 10.1016/j.jbc.2022.101972

Experimental method

X-RAY DIFFRACTION (1.63 Å)