7THX

Cryo-EM structure of W6 possum enterovirus

Summary for 7THX

• Entry DOI: 10.2210/pdb7thx/pdb
• EMDB information: 25905
• Descriptor: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... (7 entities in total)
• Functional Keywords: enterovirus, icosahedral, virus
• Biological source: Possum enterovirus W6; More
• Total number of polymer chains: 4
• Total formula weight: 91858.41

Authors

Wang, I.,Jayawardena, N.,Strauss, M.,Bostina, M. (deposition date: 2022-01-12, release date: 2022-03-09, Last modification date: 2024-06-05)

Primary citation

Wang, I.,Gupta, S.K.,Ems, G.,Jayawardena, N.,Strauss, M.,Bostina, M.
Cryo-EM Structure of a Possum Enterovirus.
Viruses, 14:-, 2022

PubMed Abstract: Enteroviruses (EVs) represent a substantial concern to global health. Here, we present the cryo-EM structure of a non-human enterovirus, EV-F4, isolated from the Australian brushtail possum to assess the structural diversity of these picornaviruses. The capsid structure, determined to ~3 Å resolution by single particle analysis, exhibits a largely smooth surface, similar to EV-F3 (formerly BEV-2). Although the cellular receptor is not known, the absence of charged residues on the outer surface of the canyon suggest a different receptor type than for EV-F3. Density for the pocket factor is clear, with the entrance to the pocket being smaller than for other enteroviruses.

PubMed: 35215909
DOI: 10.3390/v14020318

Experimental method

ELECTRON MICROSCOPY (2.96 Å)