7THX

Cryo-EM structure of W6 possum enterovirus

7THX の概要

• エントリーDOI: 10.2210/pdb7thx/pdb
• EMDBエントリー: 25905
• 分子名称: Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... (7 entities in total)
• 機能のキーワード: enterovirus, icosahedral, virus
• 由来する生物種: Possum enterovirus W6; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 91858.41

構造登録者

Wang, I.,Jayawardena, N.,Strauss, M.,Bostina, M. (登録日: 2022-01-12, 公開日: 2022-03-09, 最終更新日: 2024-06-05)

主引用文献

Wang, I.,Gupta, S.K.,Ems, G.,Jayawardena, N.,Strauss, M.,Bostina, M.
Cryo-EM Structure of a Possum Enterovirus.
Viruses, 14:-, 2022

PubMed Abstract: Enteroviruses (EVs) represent a substantial concern to global health. Here, we present the cryo-EM structure of a non-human enterovirus, EV-F4, isolated from the Australian brushtail possum to assess the structural diversity of these picornaviruses. The capsid structure, determined to ~3 Å resolution by single particle analysis, exhibits a largely smooth surface, similar to EV-F3 (formerly BEV-2). Although the cellular receptor is not known, the absence of charged residues on the outer surface of the canyon suggest a different receptor type than for EV-F3. Density for the pocket factor is clear, with the entrance to the pocket being smaller than for other enteroviruses.

PubMed: 35215909
DOI: 10.3390/v14020318

実験手法

ELECTRON MICROSCOPY (2.96 Å)