7TH5

Thermus thermophilus methylenetetrahydrofolate reductase

Summary for 7TH5

Entry DOI	10.2210/pdb7th5/pdb
Descriptor	Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, SODIUM ION, ... (4 entities in total)
Functional Keywords	tim barrel, flavin, oxidoreductase
Biological source	Thermus thermophilus HB8
Total number of polymer chains	2
Total formula weight	67718.85
Authors	Yamada, K.,Koutmos, M. (deposition date: 2022-01-10, release date: 2023-01-18, Last modification date: 2023-10-25)
Primary citation	Yamada, K.,Mendoza, J.,Koutmos, M. 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity. J.Biol.Chem., 299:102855-102855, 2022 Cited by PubMed: 36592927 DOI: 10.1016/j.jbc.2022.102855 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation