7TH4
T. thermophilus methylenetetrahydrofolate reductase complex with 5-formyltetrahydrofolate
Summary for 7TH4
Entry DOI | 10.2210/pdb7th4/pdb |
Descriptor | Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (6 entities in total) |
Functional Keywords | tim barrel, flavin, oxidoreductase, 5-formyltetrahydrofolate |
Biological source | Thermus thermophilus HB8 |
Total number of polymer chains | 2 |
Total formula weight | 68785.15 |
Authors | Yamada, K.,Koutmos, M. (deposition date: 2022-01-10, release date: 2023-01-18, Last modification date: 2023-10-25) |
Primary citation | Yamada, K.,Mendoza, J.,Koutmos, M. 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity. J.Biol.Chem., 299:102855-102855, 2022 Cited by PubMed: 36592927DOI: 10.1016/j.jbc.2022.102855 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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