7TH4

T. thermophilus methylenetetrahydrofolate reductase complex with 5-formyltetrahydrofolate

7TH4 の概要

• エントリーDOI: 10.2210/pdb7th4/pdb
• 分子名称: Methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (6 entities in total)
• 機能のキーワード: tim barrel, flavin, oxidoreductase, 5-formyltetrahydrofolate
• 由来する生物種: Thermus thermophilus HB8
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68785.15

構造登録者

Yamada, K.,Koutmos, M. (登録日: 2022-01-10, 公開日: 2023-01-18, 最終更新日: 2023-10-25)

• 主引用文献: Yamada, K.,Mendoza, J.,Koutmos, M.; 5-Formyltetrahydrofolate promotes conformational remodeling in a methylenetetrahydrofolate reductase active site and inhibits its activity.; J.Biol.Chem., 299:102855-102855, 2022; PubMed: 36592927; DOI: 10.1016/j.jbc.2022.102855

実験手法

X-RAY DIFFRACTION (1.45 Å)