7TGR

Structure of SARS-CoV-2 main protease in complex with GC376

7TGR の概要

• エントリーDOI: 10.2210/pdb7tgr/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002495
• 分子名称: 3C-like proteinase, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ... (8 entities in total)
• 機能のキーワード: protease, inhibitor, complex, hydrolase
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34716.41

構造登録者

Esler, M.A.,Shi, K.,Aihara, H.,Harris, R.S. (登録日: 2022-01-09, 公開日: 2022-05-04, 最終更新日: 2023-10-18)

• 主引用文献: Moghadasi, S.A.,Esler, M.A.,Otsuka, Y.,Becker, J.T.,Moraes, S.N.,Anderson, C.B.,Chamakuri, S.,Belica, C.,Wick, C.,Harki, D.A.,Young, D.W.,Scampavia, L.,Spicer, T.P.,Shi, K.,Aihara, H.,Brown, W.L.,Harris, R.S.; Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M pro /3CL pro in Living Cells.; Mbio, 13:e0078422-e0078422, 2022; PubMed: 35471084; DOI: 10.1128/mbio.00784-22

実験手法

X-RAY DIFFRACTION (1.68 Å)