7TBT

Co-crystal structure of SARS-CoV-2 Mpro C145A with substrate peptide 13/14

7TBT の概要

• エントリーDOI: 10.2210/pdb7tbt/pdb
• 分子名称: 3C-like proteinase, Nonstructural protein 13/14 (3 entities in total)
• 機能のキーワード: coronavirus, covid-19, covid, protease, drug resistance, complex, hydrolase, durg discovery, main protease, mpro, substrate complex, nsp 13/14, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34851.62

構造登録者

Shaqra, A.M.,Schiffer, C.A. (登録日: 2021-12-22, 公開日: 2022-06-22, 最終更新日: 2023-10-18)

• 主引用文献: Shaqra, A.M.,Zvornicanin, S.N.,Huang, Q.Y.J.,Lockbaum, G.J.,Knapp, M.,Tandeske, L.,Bakan, D.T.,Flynn, J.,Bolon, D.N.A.,Moquin, S.,Dovala, D.,Kurt Yilmaz, N.,Schiffer, C.A.; Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance.; Nat Commun, 13:3556-3556, 2022; PubMed: 35729165; DOI: 10.1038/s41467-022-31210-w

実験手法

X-RAY DIFFRACTION (2.45 Å)