7TBD

Crystal structure of Plasmepsin X from Plasmodium vivax in complex with WM382

7TBD の概要

• エントリーDOI: 10.2210/pdb7tbd/pdb
• 分子名称: Plasmepsin X, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: aspartyl protease, hydrolase
• 由来する生物種: Plasmodium vivax (malaria parasite P. vivax)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87432.07

構造登録者

Hodder, A.N.,Christensen, J.B.,Scally, S.W.,Cowman, A.F. (登録日: 2021-12-21, 公開日: 2022-05-04, 最終更新日: 2023-10-18)

• 主引用文献: Hodder, A.N.,Christensen, J.,Scally, S.,Triglia, T.,Ngo, A.,Birkinshaw, R.W.,Bailey, B.,Favuzza, P.,Dietrich, M.H.,Tham, W.H.,Czabotar, P.E.,Lowes, K.,Guo, Z.,Murgolo, N.,Lera Ruiz, M.,McCauley, J.A.,Sleebs, B.E.,Olsen, D.,Cowman, A.F.; Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax.; Structure, 30:947-, 2022; PubMed: 35460613; DOI: 10.1016/j.str.2022.03.018

実験手法

X-RAY DIFFRACTION (2.22 Å)