7TAT

SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (two receptor-binding domains open)

7TAT の概要

• エントリーDOI: 10.2210/pdb7tat/pdb
• EMDBエントリー: 25784
• 分子名称: Spike glycoprotein, S2K146 Fab heavy chain, S2K146 Fab light chain, ... (5 entities in total)
• 機能のキーワード: sars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, structural genomics, seattle structural genomics center for infectious disease, ssgcid, inhibitor, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2; 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 512834.02

構造登録者

Park, Y.J.,Seattle Structural Genomics Center for Infectious Disease (SSGCID),Veesler, D. (登録日: 2021-12-21, 公開日: 2022-01-12, 最終更新日: 2022-02-09)

• 主引用文献: Park, Y.J.,De Marco, A.,Starr, T.N.,Liu, Z.,Pinto, D.,Walls, A.C.,Zatta, F.,Zepeda, S.K.,Bowen, J.E.,Sprouse, K.R.,Joshi, A.,Giurdanella, M.,Guarino, B.,Noack, J.,Abdelnabi, R.,Foo, S.C.,Rosen, L.E.,Lempp, F.A.,Benigni, F.,Snell, G.,Neyts, J.,Whelan, S.P.J.,Virgin, H.W.,Bloom, J.D.,Corti, D.,Pizzuto, M.S.,Veesler, D.; Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry.; Science, 375:449-454, 2022; PubMed: 34990214; DOI: 10.1126/science.abm8143

実験手法

ELECTRON MICROSCOPY (3.2 Å)