7TAS
SARS-CoV-2 spike in complex with the S2K146 neutralizing antibody Fab fragment (local refinement of the RBD and S2K146)
Summary for 7TAS
Entry DOI | 10.2210/pdb7tas/pdb |
EMDB information | 25783 |
Descriptor | S2K146 Fab heavy chain, S2K146 Fab light chain, Spike glycoprotein, ... (4 entities in total) |
Functional Keywords | sars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, structural genomics, seattle structural genomics center for infectious disease, ssgcid, inhibitor, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 3 |
Total formula weight | 167655.25 |
Authors | Park, Y.J.,Veesler, D.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-12-21, release date: 2022-01-12, Last modification date: 2022-02-09) |
Primary citation | Park, Y.J.,De Marco, A.,Starr, T.N.,Liu, Z.,Pinto, D.,Walls, A.C.,Zatta, F.,Zepeda, S.K.,Bowen, J.E.,Sprouse, K.R.,Joshi, A.,Giurdanella, M.,Guarino, B.,Noack, J.,Abdelnabi, R.,Foo, S.C.,Rosen, L.E.,Lempp, F.A.,Benigni, F.,Snell, G.,Neyts, J.,Whelan, S.P.J.,Virgin, H.W.,Bloom, J.D.,Corti, D.,Pizzuto, M.S.,Veesler, D. Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry. Science, 375:449-454, 2022 Cited by PubMed: 34990214DOI: 10.1126/science.abm8143 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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