7T7D

MA-1-206-OXA-23 30s complex

7T7D の概要

• エントリーDOI: 10.2210/pdb7t7d/pdb
• 分子名称: Beta-lactamase OXA-23, (2R,4S)-2-(1,3-dihydroxypropan-2-yl)-4-{[(3R,5R)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-3,4-dihydro-2H-pyrrole-5-carboxylic acid (3 entities in total)
• 機能のキーワード: antibiotic resistance, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28065.38

構造登録者

Smith, C.A.,Stewart, N.K.,Vakulenko, S.B. (登録日: 2021-12-15, 公開日: 2022-05-18, 最終更新日: 2023-11-15)

• 主引用文献: Stewart, N.K.,Toth, M.,Alqurafi, M.A.,Chai, W.,Nguyen, T.Q.,Quan, P.,Lee, M.,Buynak, J.D.,Smith, C.A.,Vakulenko, S.B.; C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation.; Mbio, 13:e0036722-e0036722, 2022; PubMed: 35420470; DOI: 10.1128/mbio.00367-22

実験手法

X-RAY DIFFRACTION (2.65 Å)