7T6F
Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Summary for 7T6F
Entry DOI | 10.2210/pdb7t6f/pdb |
EMDB information | 25715 |
Descriptor | Tyrosine-protein kinase, Interferon lambda receptor 1, ADENOSINE, ... (4 entities in total) |
Functional Keywords | signaling complex, janus kinase, jak, oncogenic mutation, gain-of-function mutation, cytokine receptor, signaling protein |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 4 |
Total formula weight | 293233.32 |
Authors | Glassman, C.R.,Tsutsumi, N.,Jude, K.M.,Garcia, K.C. (deposition date: 2021-12-13, release date: 2022-03-16, Last modification date: 2024-02-28) |
Primary citation | Glassman, C.R.,Tsutsumi, N.,Saxton, R.A.,Lupardus, P.J.,Jude, K.M.,Garcia, K.C. Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Science, 376:163-169, 2022 Cited by PubMed: 35271300DOI: 10.1126/science.abn8933 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.6 Å) |
Structure validation
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