7T6F

Structure of active Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain

Summary for 7T6F

• Entry DOI: 10.2210/pdb7t6f/pdb
• EMDB information: 25715
• Descriptor: Tyrosine-protein kinase, Interferon lambda receptor 1, ADENOSINE, ... (4 entities in total)
• Functional Keywords: signaling complex, janus kinase, jak, oncogenic mutation, gain-of-function mutation, cytokine receptor, signaling protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 293233.32

Authors

Glassman, C.R.,Tsutsumi, N.,Jude, K.M.,Garcia, K.C. (deposition date: 2021-12-13, release date: 2022-03-16, Last modification date: 2024-02-28)

• Primary citation: Glassman, C.R.,Tsutsumi, N.,Saxton, R.A.,Lupardus, P.J.,Jude, K.M.,Garcia, K.C.; Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation.; Science, 376:163-169, 2022; PubMed: 35271300; DOI: 10.1126/science.abn8933

Experimental method

ELECTRON MICROSCOPY (3.6 Å)