7T4X

AKT1 K+ channel from A. thaliana in MSP2N2 lipid nanodisc

7T4X の概要

• エントリーDOI: 10.2210/pdb7t4x/pdb
• EMDBエントリー: 25691
• 分子名称: Potassium channel AKT1, POTASSIUM ION, PHOSPHATIDYLETHANOLAMINE, ... (4 entities in total)
• 機能のキーワード: k+ channel, ion channel, hyperpolarization-activated channel, voltage-gated channel, membrane protein
• 由来する生物種: Arabidopsis thaliana (thale cress)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 390102.07

構造登録者

Dickinson, M.S.,Pourmal, S. (登録日: 2021-12-10, 公開日: 2021-12-22, 最終更新日: 2024-11-06)

主引用文献

Dickinson, M.S.,Pourmal, S.,Gupta, M.,Bi, M.,Stroud, R.M.
Symmetry Reduction in a Hyperpolarization-Activated Homotetrameric Ion Channel.
Biochemistry, 61:2177-2181, 2022

PubMed Abstract: Plants obtain nutrients from the soil via transmembrane transporters and channels in their root hairs, from which ions radially transport in toward the xylem for distribution across the plant body. We determined structures of the hyperpolarization-activated channel AKT1 from , which mediates K uptake from the soil into plant roots. These structures of AtAKT1 embedded in lipid nanodiscs show that the channel undergoes a reduction of C4 to C2 symmetry, possibly to regulate its electrical activation.

PubMed: 34964607
DOI: 10.1021/acs.biochem.1c00654

実験手法

ELECTRON MICROSCOPY (2.8 Å)