7T3X

Structure of unphosphorylated Pediculus humanus (Ph) PINK1 D334A mutant

Summary for 7T3X

Entry DOI	10.2210/pdb7t3x/pdb
Descriptor	Serine/threonine-protein kinase PINK1 (1 entity in total)
Functional Keywords	pink1, kinase, transferase, mitophagy, parkinson's disease, ubiquitin, phosphorylation, phospho-ubiquitin
Biological source	Pediculus humanus corporis (human body louse)
Total number of polymer chains	1
Total formula weight	52929.61
Authors	Gan, Z.Y.,Leis, A.,Dewson, G.,Glukhova, A.,Komander, D. (deposition date: 2021-12-09, release date: 2021-12-22, Last modification date: 2023-10-18)
Primary citation	Gan, Z.Y.,Callegari, S.,Cobbold, S.A.,Cotton, T.R.,Mlodzianoski, M.J.,Schubert, A.F.,Geoghegan, N.D.,Rogers, K.L.,Leis, A.,Dewson, G.,Glukhova, A.,Komander, D. Activation mechanism of PINK1. Nature, 602:328-335, 2022 Cited by PubMed: 34933320 DOI: 10.1038/s41586-021-04340-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.53 Å)

Structure validation