7T27

Structure of phage FBB1 anti-CBASS nuclease Acb1-3'3'-cGAMP complex in post reaction state

Summary for 7T27

Entry DOI	10.2210/pdb7t27/pdb
Descriptor	Acb1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-2-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphoryl]oxymethyl]-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphinic acid, SULFATE ION, ... (4 entities in total)
Functional Keywords	anti-cbass, nuclease, immune evasion, viral protein
Biological source	Erwinia phage FBB1
Total number of polymer chains	1
Total formula weight	17085.75
Authors	Hobbs, S.J.,Wein, T.,Lu, A.,Morehouse, B.R.,Schnabel, J.,Sorek, R.,Kranzusch, P.J. (deposition date: 2021-12-03, release date: 2022-04-20, Last modification date: 2024-02-28)
Primary citation	Hobbs, S.J.,Wein, T.,Lu, A.,Morehouse, B.R.,Schnabel, J.,Leavitt, A.,Yirmiya, E.,Sorek, R.,Kranzusch, P.J. Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature, 605:522-526, 2022 Cited by PubMed: 35395152 DOI: 10.1038/s41586-022-04716-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation