7T27

Structure of phage FBB1 anti-CBASS nuclease Acb1-3'3'-cGAMP complex in post reaction state

7T27 の概要

• エントリーDOI: 10.2210/pdb7t27/pdb
• 分子名称: Acb1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-2-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphoryl]oxymethyl]-4-oxidanyl-oxolan-3-yl]oxy-sulfanyl-phosphinic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: anti-cbass, nuclease, immune evasion, viral protein
• 由来する生物種: Erwinia phage FBB1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17085.75

構造登録者

Hobbs, S.J.,Wein, T.,Lu, A.,Morehouse, B.R.,Schnabel, J.,Sorek, R.,Kranzusch, P.J. (登録日: 2021-12-03, 公開日: 2022-04-20, 最終更新日: 2024-02-28)

• 主引用文献: Hobbs, S.J.,Wein, T.,Lu, A.,Morehouse, B.R.,Schnabel, J.,Leavitt, A.,Yirmiya, E.,Sorek, R.,Kranzusch, P.J.; Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity.; Nature, 605:522-526, 2022; PubMed: 35395152; DOI: 10.1038/s41586-022-04716-y

実験手法

X-RAY DIFFRACTION (1.2 Å)