7T1Y
Structure of the Fbw7-Skp1-MycCdegron complex
Summary for 7T1Y
| Entry DOI | 10.2210/pdb7t1y/pdb |
| Descriptor | S-phase kinase-associated protein 1, F-box/WD repeat-containing protein 7, Myc proto-oncogene protein C terminal degron, ... (5 entities in total) |
| Functional Keywords | ubiquitin ligase, wd40, ligase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 73350.72 |
| Authors | Wang, B.,Rusnac, D.V.,Clurman, B.E.,Zheng, N. (deposition date: 2021-12-02, release date: 2022-02-16, Last modification date: 2023-10-18) |
| Primary citation | Welcker, M.,Wang, B.,Rusnac, D.V.,Hussaini, Y.,Swanger, J.,Zheng, N.,Clurman, B.E. Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor. Sci Adv, 8:eabl7872-eabl7872, 2022 Cited by PubMed: 35089787DOI: 10.1126/sciadv.abl7872 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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