7SWI
cTnC-TnI chimera complexed with A2
Summary for 7SWI
Entry DOI | 10.2210/pdb7swi/pdb |
NMR Information | BMRB: 30966 |
Descriptor | Troponin C, slow skeletal and cardiac muscles,Troponin I, cardiac muscle chimera, 4-(3-cyano-3-methylazetidine-1-carbonyl)-N-[(3R,4S)-7-fluoro-4-hydroxy-6-methyl-3,4-dihydro-2H-1-benzopyran-3-yl]-5-methyl-1H-pyrrole-2-sulfonamide (2 entities in total) |
Functional Keywords | cardiac troponin, calcium sensitizer, metal binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 14684.62 |
Authors | Poppe, L.,Hartman, J.J.,Romero, A.,Reagan, J.D. (deposition date: 2021-11-19, release date: 2022-04-06, Last modification date: 2024-05-15) |
Primary citation | Poppe, L.,Hartman, J.J.,Romero, A.,Reagan, J.D. Structural and Thermodynamic Model for the Activation of Cardiac Troponin. Biochemistry, 61:741-748, 2022 Cited by PubMed: 35349258DOI: 10.1021/acs.biochem.2c00084 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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