7SV8

Carbonic Anhydrase IX-mimic Complexed with 3-((2-((Furan-2-ylmethyl)(4-sulfamoylphenethyl)amino)-2-oxoethyl)(phenethyl)amino)propanoic acid

7SV8 の概要

• エントリーDOI: 10.2210/pdb7sv8/pdb
• 分子名称: Carbonic anhydrase 2, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ZINC ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, carbonic anhydrase, metal binding protein, lyase-inhibitor complex, lyase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29605.72

構造登録者

Combs, J.E.,McKenna, R. (登録日: 2021-11-18, 公開日: 2022-04-06, 最終更新日: 2023-10-18)

• 主引用文献: Bonardi, A.,Bua, S.,Combs, J.,Lomelino, C.,Andring, J.,Osman, S.M.,Toti, A.,Di Cesare Mannelli, L.,Gratteri, P.,Ghelardini, C.,McKenna, R.,Nocentini, A.,Supuran, C.T.; The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII.; J Enzyme Inhib Med Chem, 37:930-939, 2022; PubMed: 35306936; DOI: 10.1080/14756366.2022.2053526

実験手法

X-RAY DIFFRACTION (1.388 Å)