7SUH

Structure of CHK1 10-pt. mutant complex with LRRK2 inhibitor 15

Summary for 7SUH

• Entry DOI: 10.2210/pdb7suh/pdb
• Descriptor: Serine/threonine-protein kinase Chk1, 1-[5-chloro-4-({6-chloro-7-[1-(oxetan-3-yl)piperidin-4-yl]quinazolin-2-yl}amino)-1H-pyrazol-1-yl]-2-methylpropan-2-ol (3 entities in total)
• Functional Keywords: kinase, parkinson's disease, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 34585.62

Authors

Palte, R.L. (deposition date: 2021-11-17, release date: 2022-01-12, Last modification date: 2023-10-18)

• Primary citation: Keylor, M.H.,Gulati, A.,Kattar, S.D.,Johnson, R.E.,Chau, R.W.,Margrey, K.A.,Ardolino, M.J.,Zarate, C.,Poremba, K.E.,Simov, V.,Morriello, G.J.,Acton, J.J.,Pio, B.,Yan, X.,Palte, R.L.,McMinn, S.E.,Nogle, L.,Lesburg, C.A.,Adpressa, D.,Lin, S.,Neelamkavil, S.,Liu, P.,Su, J.,Hegde, L.G.,Woodhouse, J.D.,Faltus, R.,Xiong, T.,Ciaccio, P.J.,Piesvaux, J.,Otte, K.M.,Wood, H.B.,Kennedy, M.E.,Bennett, D.J.,DiMauro, E.F.,Fell, M.J.,Fuller, P.H.; Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.; J.Med.Chem., 65:838-856, 2022; PubMed: 34967623; DOI: 10.1021/acs.jmedchem.1c01968

Experimental method

X-RAY DIFFRACTION (2.46 Å)