7SS7

Crystal structure of Klebsiella LpxH in complex with JH-LPH-50

7SS7 の概要

• エントリーDOI: 10.2210/pdb7ss7/pdb
• 分子名称: UDP-2,3-diacylglucosamine hydrolase, MANGANESE (II) ION, 6-{[(4-{4-[3-chloro-5-(trifluoromethyl)phenyl]piperazine-1-sulfonyl}phenyl)carbamoyl]amino}-N-hydroxyhexanamide, ... (5 entities in total)
• 機能のキーワード: lpxh, lipid a, lps, antibiotic, gram-negative bacteria, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30701.99

構造登録者

Cho, J.,Cochrane, C.S.,Zhou, P. (登録日: 2021-11-09, 公開日: 2023-04-12, 最終更新日: 2023-10-25)

• 主引用文献: Kwak, S.H.,Skyler Cochrane, C.,Cho, J.,Dome, P.A.,Ennis, A.F.,Kim, J.H.,Zhou, P.,Hong, J.; Development of LpxH Inhibitors Chelating the Active Site Dimanganese Metal Cluster of LpxH.; Chemmedchem, 18:e202300023-e202300023, 2023; PubMed: 37014664; DOI: 10.1002/cmdc.202300023

実験手法

X-RAY DIFFRACTION (1.73 Å)