7SOB

SARS-CoV-2 S B.1.617.1 kappa variant + S309 + S2L20 Global Refinement

7SOB の概要

• エントリーDOI: 10.2210/pdb7sob/pdb
• 関連するPDBエントリー: 7SO9
• EMDBエントリー: 25265
• 分子名称: Spike glycoprotein, S2L20 Fab light chain, S2L20 Fab heavy chain, ... (7 entities in total)
• 機能のキーワード: kappa, spike, antibody, structural genomics, seattle structural genomics center for infectious disease, ssgcid, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 15
• 化学式量合計: 586473.12

構造登録者

McCallum, M.,Veesler, D.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2021-10-29, 公開日: 2021-11-17, 最終更新日: 2024-10-16)

主引用文献

McCallum, M.,Walls, A.C.,Sprouse, K.R.,Bowen, J.E.,Rosen, L.E.,Dang, H.V.,De Marco, A.,Franko, N.,Tilles, S.W.,Logue, J.,Miranda, M.C.,Ahlrichs, M.,Carter, L.,Snell, G.,Pizzuto, M.S.,Chu, H.Y.,Van Voorhis, W.C.,Corti, D.,Veesler, D.
Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants.
Science, 374:1621-1626, 2021

PubMed Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission leads to the emergence of variants, including the B.1.617.2 (Delta) variant of concern that is causing a new wave of infections and has become globally dominant. We show that these variants dampen the in vitro potency of vaccine-elicited serum neutralizing antibodies and provide a structural framework for describing their immune evasion. Mutations in the B.1.617.1 (Kappa) and Delta spike glycoproteins abrogate recognition by several monoclonal antibodies via alteration of key antigenic sites, including remodeling of the Delta amino-terminal domain. The angiotensin-converting enzyme 2 binding affinities of the Kappa and Delta receptor binding domains are comparable to the Wuhan-Hu-1 isolate, whereas B.1.617.2+ (Delta+) exhibits markedly reduced affinity.

PubMed: 34751595
DOI: 10.1126/science.abl8506

実験手法

ELECTRON MICROSCOPY (2.4 Å)