7SO4
Crystal Structure of HIV-1 Y181C mutant Reverse Transcriptase in Complex with 5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)phenoxy)-7-fluoro-2-naphthonitrile (JLJ635), a Non-nucleoside Inhibitor
Summary for 7SO4
Entry DOI | 10.2210/pdb7so4/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]phenoxy}-7-fluoronaphthalene-2-carbonitrile, ... (5 entities in total) |
Functional Keywords | nnrtis, hiv-1, drug design, transferase, hydrolase, transferase-viral protein complex, transferase/viral protein |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) More |
Total number of polymer chains | 2 |
Total formula weight | 114482.15 |
Authors | Bertoletti, N.,Anderson, K.S.,Cisneros Trigo, J.A.,Jorgensen, W.L.,Frey, K.M.,Chan, A.H. (deposition date: 2021-10-29, release date: 2022-03-16, Last modification date: 2023-10-18) |
Primary citation | Frey, K.M.,Bertoletti, N.,Chan, A.H.,Ippolito, J.A.,Bollini, M.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci, 9:805187-805187, 2022 Cited by PubMed: 35237658DOI: 10.3389/fmolb.2022.805187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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