7SNP
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-(2-morpholinoethoxy)phenoxy)phenyl)acrylonitrile (JLJ530)
Summary for 7SNP
Entry DOI | 10.2210/pdb7snp/pdb |
Descriptor | Reverse transcriptase p66, p51 RT, (2E)-3-(3-chloro-5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-[2-(morpholin-4-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, ... (4 entities in total) |
Functional Keywords | polymerase, transferase, hydrolase, rnaseh, transferase-viral protein complex, transferase/viral protein |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Total number of polymer chains | 2 |
Total formula weight | 114567.71 |
Authors | Frey, K.M.,Anderson, K.S. (deposition date: 2021-10-28, release date: 2022-03-16, Last modification date: 2023-10-18) |
Primary citation | Frey, K.M.,Bertoletti, N.,Chan, A.H.,Ippolito, J.A.,Bollini, M.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci, 9:805187-805187, 2022 Cited by PubMed: 35237658DOI: 10.3389/fmolb.2022.805187 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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