7SNP
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with (E)-3-(3-chloro-5-(2-(2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy)-4-(2-morpholinoethoxy)phenoxy)phenyl)acrylonitrile (JLJ530)
7SNP の概要
エントリーDOI | 10.2210/pdb7snp/pdb |
分子名称 | Reverse transcriptase p66, p51 RT, (2E)-3-(3-chloro-5-{2-[2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethoxy]-4-[2-(morpholin-4-yl)ethoxy]phenoxy}phenyl)prop-2-enenitrile, ... (4 entities in total) |
機能のキーワード | polymerase, transferase, hydrolase, rnaseh, transferase-viral protein complex, transferase/viral protein |
由来する生物種 | Human immunodeficiency virus type 1 (HIV-1) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 114567.71 |
構造登録者 | |
主引用文献 | Frey, K.M.,Bertoletti, N.,Chan, A.H.,Ippolito, J.A.,Bollini, M.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Structural Studies and Structure Activity Relationships for Novel Computationally Designed Non-nucleoside Inhibitors and Their Interactions With HIV-1 Reverse Transcriptase. Front Mol Biosci, 9:805187-805187, 2022 Cited by PubMed: 35237658DOI: 10.3389/fmolb.2022.805187 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.89 Å) |
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検証レポート(詳細版)
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