7SMU

Crystal Structure of Consomatin-Ro1

7SMU の概要

• エントリーDOI: 10.2210/pdb7smu/pdb
• 分子名称: Consomatin-Ro1, 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45-pentadecaoxaoctatetracontane-1,48-diol (3 entities in total)
• 機能のキーワード: cone snail, venom, consomatin-ro1, somatostatin, sst mimetic, disulfide, toxin
• 由来する生物種: Conus rolani
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 10203.94

構造登録者

Ramiro, I.B.L.,Whitby, F.G.,Hill, C.P.,Safavi-Hemami, H.,Concepcion, G.P.,Olivera, B.M. (登録日: 2021-10-26, 公開日: 2022-04-13)

主引用文献

Ramiro, I.B.L.,Bjorn-Yoshimoto, W.E.,Imperial, J.S.,Gajewiak, J.,Salcedo, P.F.,Watkins, M.,Taylor, D.,Resager, W.,Ueberheide, B.,Brauner-Osborne, H.,Whitby, F.G.,Hill, C.P.,Martin, L.F.,Patwardhan, A.,Concepcion, G.P.,Olivera, B.M.,Safavi-Hemami, H.
Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads.
Sci Adv, 8:eabk1410-eabk1410, 2022

PubMed Abstract: Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has generated a diverse set of SS analogs, each optimized to elicit specific systemic physiological effects in prey. The increased metabolic stability, distinct SS receptor activation profiles, and chemical diversity of the venom analogs make them suitable leads for therapeutic application, including pain, cancer, and endocrine disorders. Our findings not only establish the existence of SS-like peptides in animal venoms but also serve as a model for the synergy gained from combining molecular phylogenetics and behavioral observations to optimize the discovery of natural products with biomedical potential.

PubMed: 35319982
DOI: 10.1126/sciadv.abk1410

実験手法

X-RAY DIFFRACTION (1.95 Å)