7SJ4
Human Trio residues 1284-1959 in complex with Rac1
Summary for 7SJ4
Entry DOI | 10.2210/pdb7sj4/pdb |
EMDB information | 25153 |
Descriptor | Triple functional domain protein, Ras-related C3 botulinum toxin substrate 1 (3 entities in total) |
Functional Keywords | guanine nucleotide exchange factor, gtpase, dbl homology, pleckstrin homology, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 97404.42 |
Authors | Chen, C.-L.,Ravala, S.K.,Bandekar, S.J.,Cash, J.,Tesmer, J.J.G. (deposition date: 2021-10-15, release date: 2022-07-06, Last modification date: 2024-06-05) |
Primary citation | Bandekar, S.J.,Chen, C.L.,Ravala, S.K.,Cash, J.N.,Avramova, L.V.,Zhalnina, M.V.,Gutkind, J.S.,Li, S.,Tesmer, J.J.G. Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1. J.Biol.Chem., 298:102209-102209, 2022 Cited by PubMed: 35779635DOI: 10.1016/j.jbc.2022.102209 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.86 Å) |
Structure validation
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