7SJ4

Human Trio residues 1284-1959 in complex with Rac1

7SJ4 の概要

• エントリーDOI: 10.2210/pdb7sj4/pdb
• EMDBエントリー: 25153
• 分子名称: Triple functional domain protein, Ras-related C3 botulinum toxin substrate 1 (3 entities in total)
• 機能のキーワード: guanine nucleotide exchange factor, gtpase, dbl homology, pleckstrin homology, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97404.42

構造登録者

Chen, C.-L.,Ravala, S.K.,Bandekar, S.J.,Cash, J.,Tesmer, J.J.G. (登録日: 2021-10-15, 公開日: 2022-07-06, 最終更新日: 2024-06-05)

• 主引用文献: Bandekar, S.J.,Chen, C.L.,Ravala, S.K.,Cash, J.N.,Avramova, L.V.,Zhalnina, M.V.,Gutkind, J.S.,Li, S.,Tesmer, J.J.G.; Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.; J.Biol.Chem., 298:102209-102209, 2022; PubMed: 35779635; DOI: 10.1016/j.jbc.2022.102209

実験手法

ELECTRON MICROSCOPY (2.86 Å)